Prostate Health

The prostate gland is vaguely understood by most guys. For one thing, men just don’t think about their health as much as women do. In all likelihood, this costs men much of the 5 year life- expectancy gap between the genders. The prostate is also a sexual organ, which contributes to the tendency to neglect it. It is the major source of seminal fluid and therefore connected to a man’s sexuality. Unfortunately, Prostate Cancer is the biggest cancer killer of non-smoking men and the second biggest cancer killer overall.

What to do about this fact has become one of the biggest controversies in medicine.

The American Cancer Society (ACS) recommends annual Prostate Specific Antigen (PSA) testing beginning at age 50 (or earlier for African- American men or other men with a family history of early prostate cancer). The PSA is a simple blood test. When cancer is detected it is usually aggressively treated. The ACS website however states that while the risks and harms of such a screening program (and aggressive treatment) are clear, the benefits are not. Many experts in prevention and epidemiology highly doubt that there is much if any benefit. It’s a perplexing story.

Prostate cancer is extremely prevalent. Over 200,000 new cases of Prostate Cancer are diagnosed annually and over 40,000 men will die of prostate cancer in the United States this year (But recall that most cases of prostate cancer are never diagnosed.) Prostate cancer ranks second following lung cancer as the underlying cause of cancer death, accounting for approximately 13% of all cancer mortality and 2.5-3.0% of all deaths among males. African-American men have a greater risk than Caucasians or other ethnic groups in the United States, and have one of the highest rates of Prostate Cancer in the world. Autopsy series have shown that 90% of 90+ year old men have prostate cancer, although, again- most of them never know it.

Overall mortality of prostate cancer is well under 10%, and possibly as low as 1% – 4%. This ambiguity is due to ever increasing rates of detection of Prostate Cancer cases (with PSA testing) that were not diagnosed previously and the fact that most cases of Prostate cancer cases are never detected. The overwhelming majority of men with prostate cancer will die of something else! 98% of men with prostate cancer, who haven’t died of something else, will be alive and well 15 years after diagnosis. TheverylowaggressivenessandlethalityofProstatecancerisverydifferentfrommost other cancers, yet – and here is the perplexity again – its extremely high prevalence combined with low mortality still makes it the number one cancer killer of non smoking men. In any case, it’s hard to improve upon 1% – 4% mortality. It means that you have to treat at least 25 – 100 men to prevent 1 death from prostate cancer (if indeed treatment has some efficacy, which is not clear). For men with localized prostate cancer, “acceptable” treatment options include radical prostatectomy, radiation therapy, cryotherapy, early androgen-suppression therapy, and watchful waiting. There is substantial risk from most of these approaches.

These are all considered acceptable options because data do not provide clear-cut evidence for the superiority of any 1 treatment. The only RCT comparing surgery to watchful waiting, though of relatively small size and conducted before PSA testing, showed no difference in survival after 23 years of follow-up. Watchful waiting entails regular monitoring of the Prostate Cancer, and treatment only of those few that act more aggressively. In Europe, this is the predominant approach, and their results are similar mortality, but with many fewer side effects and much less cost. Studies of this approach are cautiously favorable. This is clearly the correct approach for older men (>65), but remains controversial for younger men.

There is much more that can be done in prevention and treatment of prostate cancer – by “natural” means. While the “evidence” behind what follows is not truly proof, there is very little down side to eating less red meat, less milk, less white bread, and more fish, more vegetables and some supplements. There is proof that this will lower your risk of heart attack or stoke, and I believe the evidence is strong that it will reduce your risk of Prostate Cancer or reduce the risk of spread if you already have Prostate Cancer.

There is a 30-fold difference in prostate cancer risk observed between nations having the very lowest rates such as China and Japan and those exhibiting the highest risk of prostate cancer such as the economically developed nations of North America, western and northern Europe, and Australia However, the death rate of Prostate Cancer is climbing in Japan. Moreover, when Japanese men migrate to the USA they acquire nearly the same death rates as Americans. These facts point to the likely central role of diet. Here is how you can achieve these important dietary objectives.

The amount and type of fats in the diet may make a large difference in the development and spread of Prostate Cancer. Animal fats – meat and dairy are implicated. Olive and corn oil are not implicated. Cold water ocean fish fats (omega-3 fatty acids) on the other hand are probably protective. Please note that fish can bioaccumulate toxins, which include heavy metals and pesticides. Since world fish stocks are being depleted rapidly, consider some alternatives to fish for obtaining some omega-3 fatty acids. Many people prefer Flax seed oil as a source of Omega-3’s, yet pure flax seed oil has been shown to increase Prostate Cancer risk, but whole flax seeds have a strong anti-prostate cancer factor called Lignan. If you are going to eat Flax Seed Oil, make sure it is high in Lignan. Range fed chicken eggs are a particularly good source of omega-3’s as are Walnuts.

Lycopene reduces the risk of prostate cancer as well as a variety of other cancers and also heart disease! Lycopene is a red-colored carotenoid, of which 85% of our dietary uptake comes from tomato fruit and tomato-based products. The rest comes from watermelon, strawberry, pink grapefruit, guava and papaya. Of the tomato products, juice, ketchup, soup, pizza and spaghetti sauces are the major contributors in the diet.

Taken as a group, Fruit consumption does not reduce the risk of prostate cancer (except for Apples and Watermelon), while Vegetable consumption is significantly associated with a reduction in prostate cancer. Legumes including soy foods or other beans, are inversely related to prostate cancer risk, as is the intake of yellow-orange (carrots, corn and squash) and cruciferous (cabbage, Brussels sprouts, broccoli,cauliflower) vegetables. Onions and tea also reduce risk.

Supplements are probably a good idea. Vitamins and minerals may lower the risk of Prostate Cancer. There is evidence for beta-carotene (pro-Vitamin A), Vitamin C, Vitamin D, Vitamin E, Zinc and Selenium supplementation (among those with low baseline levels). Overall, however, Vegetable consumption is more important. Organic vegetables have more Selenium than conventionally grown.

Lycopene and Selenium may be the best capsulated foods, if you really want a supplement. Lycopene may not only prevent cancer, it has been shown useful in treatment! Lycopene at 25 mg, 2 times daily, for only 3 weeks helped confine Prostate Cancer to the prostate and resulted in smaller tumors. Selenium at 200 ug per day has been shown to reduce the risk of prostate cancer by 63% in 10 years.

Prostate cancer is strongly associated with the consumption of calcium and the nonfat portion of milk. High consumption of dairy products was associated with a 50% increased risk of prostate cancer. Calcium may reduce circulating amounts of vitamin D, which may increase the risk of prostate cancer. Vitamin D has been shown to inhibit prostate cancer cell growth. It is quite possible that Vitamin D supplements may be useful in preventing or treating Prostate Cancer, but this has not yet been proven.

Benign Prostatic Enlargement (aka Benign Prostatic Hypertrophy or BPH)
The prostate gland enlarges with age, even if there is no prostate cancer. This leads to a weaker stream of urine, and urinating more frequently. When this occurs at night, sleep can be disturbed. There are some medications that help for this. Occasionally, surgery is needed. Also, though not shown to prevent Prostate Cancer, Saw Palmetto does reduce the symptoms of Benign Prostatic Hypertrophy (BPH).

1. Changing Dietary Patterns and Cancer Prevention: Alpha- Linolenic Acid Health Risks and Benefits,” Colditz GA, Cancer Causes Control, 2000;11:677-678.

2. Active surveillance with selective delayed intervention: walking the line between overtreatment for indolent disease and undertreatment for aggressive disease. Klotz LH. Can J Urol. 2005 Feb;12 Suppl 1:53-7; discussion 101-2.

3. Clarifying uncertainty regarding detection and treatment of early-stage prostate cancer. Wilt TJ. Semin Urol Oncol. 2002 Feb;20(1):10-7

4. Dietary Fat Intake and Prostate Cancer Risk: A Case-Control Study in Spain,” Ramon JM, Bou R, Romea S, et al, Cancer Causes Control, 2000;11:679-685

5. Vegetables, Fruits, Legumes and Prostate Cancer: A Multiethnic Case-Control Study,” Kolonel LN, Hankin JH, Whittemore AS, et al, Cancer Epidemiol Biomarkers Prev, August 2000;9:795-804.

6. Is Lycopene Beneficial to Human Health?” Bramley PM, Phytochemistry, 2000;54:233-236.

7. Carotene Supplementation for Patients With Low Baseline Levels and Decreased Risks of Total and Prostate Carcinoma,” Cook NR, Stampfer MJ, Ma J, et al, Cancer, November 1, 1999;86(9):1783-1792.

8. Are Increasing 5-Year Survival Rates Evidence of Success Against Cancer?” Welch HG, Schwartz LM, Woloshin S, JAMA, June 14, 2000;283(22):2975-2978.

9. Fruit and Vegetable Intakes and Prostate Cancer Risk,” Cohen JH, Kristal AR, Stanford JL, J Natl Cancer Inst,
January 5, 2000;92(1):61-68

10. Pigments in Fruits, Vegetables Fight Cancer, Aid Vision,” Colchamiro R, Medical Tribune, December, 1999:8.

11. Prostate Cancer Risk and Consumption of Fish Oils: A Dietary Biomarker-Based Case-Control Study,” Norrish AE, Skeaff CM, et al, Br J Cancer, 1999;81(7):1238-1242.

12. Fish Consumption, Cancer, and Alzheimer Disease,” Grant WB, Am J Clin Nutr, 2000;71:599-603.

13. Dairy Products May Increase the Risk of Prostate Cancer,” Nutrition Week, April 28, 2000;30(17): 7/Morning Call, April 5, 2000:A10.

14. Vitamin and Mineral Supplement Use Is Associated With Reduced Risk of Prostate Cancer,” Kristal AR, etal, Cancer Epidemiol Biomarkers Prev, October, 1999;8:887-892.

15. Flaxseed Supplements May Slow Prostate Ca,” Moon MA, Family Practice News, November 15, 1999;29(22):24.

16. Dairy Products, Calcium, Phosphorus, Vitamin D, and Risk of Prostate Cancer (Sweden),” Chan JM, etal, Cancer Causes Control, 1998;9:559-566.

17. Dietary Fat and Prostate Cancer Progression and Survival,” Fradet Y, et al, Eur Urol, 1999;35:388-391.

18. Lipoxygenase Inhibition in Prostate Cancer,” Myers CE and Ghosh J, Eur Urol, 1999;35:395-398.

19. Does High Soy Milk Intake Reduce Prostate Cancer Incidence? The Adventist Health Study (United States),” Jacobsen BK, et al, Cancer Causes Control, 1998;9:553-557.

20. Diet and Its Preventive Role in Prostatic Disease,” Denis L, et al, Eur Urol, 1999;35:377-387.

21. Lycopene May Reduce Prostate Ca Tumor Grade,” Zoler ML, Family Practice News, May 15, 1999;28.

22. Diet, Micronutrients, and the Prostate Gland,” Thomas JA, Nutr Rev, April, 1999;57(4):95-103.

23. Prostate Cancer and Supplementation With a-Tocopherol and -Carotene: Incidence and Mortality in a Controlled Trial,” Heinonen, Olli P., et al, Journal of the National Cancer Institute, March 18, 1998;90(6):440-446

24. Tomatoes, Lycopene and Prostate Cancer,” Giovannucci, Edward and Clinton , StevenK., Proceedings of the Society for Experimental Biology and Medicine, 1998;218:129-139.

25. Decreased Incidence of Prostate Cancer With Selenium Supplementation: Results of a Double-Blind Cancer Prevention Trial,” Clark LC, et al, J A N A, Winter, 1999;2(1):14-18.

26. Diet, Nutrition, and Prostate Cancer,” Clinton SK and Giovannucci E, Annu Rev Nutr, 1998;18:413-440.

27. Dietary Phytochemical Research Demonstrates Potential for Major Role in Cancer Prevention,” Primary Care & Cancer, 1996;16(7):6-7.

28. Cancer and Tomatoes,” Nutrition Week, December 15, 1995;7/ Journal of the National Cancer Institute, December 6, 1995

29. High 10 Year Survival Rate in Patients With Early, Untreated Prostate Cancer”, Johansson, Jan-Erik, M.D., Ph.D., et al, JAMA, April 22/29, 1992;267(6):2191-2196.

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